[5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

Base Information

Chemical Name:[5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol
CAS No.:852949-31-6
Molecular Formula:C₃₃H₄₆O₄Si
Molecular Weight:534.811
Hs Code.:

Synonyms:[5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

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Chemical Property of [5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

Chemical Property:

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Technology Process of [5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

There total 8 articles about [5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 108-86-1,52753-63-6
bromobenzene

: 852949-19-0
5-(2,6-dimethyl-4-triisopropylsilanyloxybenzyl)-2-methoxymethoxy-benzaldehyde

: 852949-31-6
[5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

Guidance literature:: bromobenzene; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

5-(2,6-dimethyl-4-triisopropylsilanyloxybenzyl)-2-methoxymethoxy-benzaldehyde; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 2h;

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 852949-31-6
[5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / dichloromethane / 2.67 h / 10 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

4.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

4.2: 2 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 2 h / -78 - 20 °C

With 1H-imidazole; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; acetic acid; ethyl acetate;

Reference yield:

: 852949-17-8
(2,6-dimethyl-4-triisopropylsilanyloxyphenyl)-(4-methoxymethoxyphenyl)methanol

: 852949-31-6
[5-(2,6-dimethyl-4-triisopropylsilanyloxy-benzyl)-2-methoxymethoxy-phenyl]-phenyl-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium on activated charcoal / acetic acid; ethyl acetate / 5 h / 20 °C / 760.05 Torr

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; diethyl ether / 1 h / -20 - 0 °C

2.2: 2 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 2 h / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; acetic acid; ethyl acetate;