propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 86781-01-3
• Molecular Formula: C₂₁H₂₄N₂O₇
• Molecular Weight: 416.431

Synonyms:propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

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Technology Process of propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 7 articles about propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

Propyl 2,2-ethylenedioxypropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (86780-91-8) → propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (86781-01-3)

Guidance literature:

With methanesulfonic acid; water; In ethanol; for 6h; Heating;

DOI:10.1248/cpb.34.1589

Reference yield:

n-propyl acetoacetate (1779-60-8) → propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (86781-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / AcOH, piperidine / benzene / 4 h / Ambient temperature

2: 58 percent / ethanol / Heating

3: 40 percent / MeSO₃H, H₂O / ethanol / 6 h / Heating

With piperidine; methanesulfonic acid; water; acetic acid; In ethanol; benzene;

DOI:10.1248/cpb.34.1589

Reference yield:

3-nitro-benzaldehyde (99-61-6) → propyl 2-oxopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (86781-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / AcOH, piperidine / benzene / 4 h / Ambient temperature

2: 58 percent / ethanol / Heating

3: 40 percent / MeSO₃H, H₂O / ethanol / 6 h / Heating

With piperidine; methanesulfonic acid; water; acetic acid; In ethanol; benzene;

DOI:10.1248/cpb.34.1589

upstream raw materials:

Propyl 2,2-ethylenedioxypropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

n-propyl acetoacetate

3-nitro-benzaldehyde

3-amino-2-crotonic acid 2,2-ethylenedioxy propyl ester

Downstream raw materials:

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-methyl-[1,3]dithiolan-2-ylmethyl) ester 5-propyl ester

2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-methyl-[1,3]dioxan-2-ylmethyl) ester 5-propyl ester

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