2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

Base Information

Chemical Name:2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide
CAS No.:1092389-21-3
Molecular Formula:C₂₁H₂₇N₃O₅
Molecular Weight:401.462
Hs Code.:

Synonyms:2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

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Chemical Property of 2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

Chemical Property:

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Technology Process of 2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

There total 10 articles about 2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 464913-33-5
3-((2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino)-2-hydroxy-N,N-dimethylbenzamide

: 1092389-28-0
(R)-1-(5-methyltetrahydrofuran-2-yl)propylamine para-toluenesulfonate salt

: 1092389-21-3
2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃;

Reference yield:

: (R)-1-(5-methylfuran-2-yl)propylamine para-toluenesulfonate

: 1092389-21-3
2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 262.53 Torr

2: triethylamine / acetonitrile / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; acetonitrile;

Reference yield:

: 779340-44-2
(R)-2-[(R)-1-(5-methylfuran-2-yl)propylamino]-2-phenylethanol

: 1092389-21-3
2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium peroxide; methylamine / ethanol; water / 3 h / 5 - 20 °C

1.2: 1 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 262.53 Torr

3.1: triethylamine / acetonitrile / 20 °C

With sodium peroxide; hydrogen; triethylamine; methylamine; palladium 10% on activated carbon; In methanol; ethanol; water; acetonitrile;