2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol

Base Information

• Chemical Name: 2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol
• CAS No.: 1251485-62-7
• Molecular Formula: C₁₆H₁₁F₃N₂O₃
• Molecular Weight: 336.27

Synonyms:2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol

Chemical Property of 2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol

Chemical Property:

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Technology Process of 2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol

There total 1 articles about 2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(3-(benzyloxy)-4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (1251485-56-9) → 2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol (1251485-62-7)

Guidance literature:

With boron trifluoride diethyl etherate; ethanethiol; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2010.07.067

Reference yield: 92.0%

2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol (1251485-62-7) + (2S)-N-[4-(4-bromobutyl)oxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethylthioacetal (343308-56-5) → (2S)-N-{4-[4-[(5-(5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]butyl]oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethylthioacetal (1251485-77-4)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Reflux;

DOI:10.1016/j.bmc.2010.07.067

Reference yield: 85.0%

2-methoxy-5-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)phenol (1251485-62-7) + (2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal (343308-55-4) → (2S)-N-{4-[3-[(5-(5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]propyl]oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethylthioacetal (1251485-75-2)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Reflux;

DOI:10.1016/j.bmc.2010.07.067

upstream raw materials:

2-(3-(benzyloxy)-4-methoxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Downstream raw materials:

(2S)-N-{4-[3-[(5-(5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]propyl]oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethylthioacetal

(2S)-N-{4-[4-[(5-(5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]butyl]oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethylthioacetal

(2S)-N-{4-[5-[(5-(5-(4-trifluoromethylphenyl)-1,3,4-oxadiazol-2-yl)-2-methoxyphenyl)oxy]pentyl]oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethylthioacetal

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