N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide
CAS No.:1401466-18-9
Molecular Formula:C₂₅H₂₆N₈O
Molecular Weight:454.534
Hs Code.:

Synonyms:N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

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Chemical Property of N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

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Technology Process of N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

There total 4 articles about N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401466-30-5
N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

: 1401466-18-9
N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1037479-62-1
4,6-dichloro-1-(tetrahydro-2H-pyran-2-yl)-1Hpyrazolo [3 ,4-d]pyrimidine

: 1401466-18-9
N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / triphenylphosphine; palladium diacetate / toluene / 36 h / 80 °C

2: potassium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 0.67 h / 200 °C / 2280.15 Torr / sealed tube; Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With sodium carbonate; potassium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 1401466-28-1
N-(3-(6-chloro-1-(terahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

: 1401466-18-9
N-(3-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 0.67 h / 200 °C / 2280.15 Torr / sealed tube; Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With potassium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; tert-butyl alcohol;