methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

Base Information

Chemical Name:methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate
CAS No.:87787-37-9
Molecular Formula:C₁₈H₂₅BrO₄
Molecular Weight:385.298
Hs Code.:

Synonyms:methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

Chemical Property:

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Technology Process of methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

There total 16 articles about methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 87787-37-9
methyl 2-bromo-3-<4-(t-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylsulfoxide / 3 h / 30 °C

2: 2N HCl / methanol / 1 h / Ambient temperature

3: H₂ / Pd-C / methanol / 760 Torr / Ambient temperature

4: 1.) 47percent HBr, NaNO₂; 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min; 2.) 35 deg C

With copper(I) oxide; hydrogenchloride; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1248/cpb.32.2267

Reference yield:

: 64326-18-7
(±)-(1R,5S)-1-methyl-6-oxabicyclo[3.2.1]octan-7-one

: 87787-37-9
methyl 2-bromo-3-<4-(c-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

Guidance literature:: Multi-step reaction with 8 steps

1: 80.6 percent / OH^(1-)

2: diethyl ether

3: p-TsOH / diethyl ether / 2 h / Ambient temperature

4: LiAlH₄ / diethyl ether / 1 h / Ambient temperature

5: NaH / dimethylsulfoxide / 3 h / 30 °C

6: 2N HCl / methanol / 1 h / Ambient temperature

7: H₂ / Pd-C / methanol / 760 Torr / Ambient temperature

8: 1.) 47percent HBr, NaNO₂; 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min; 2.) 35 deg C

With copper(I) oxide; hydrogenchloride; lithium aluminium tetrahydride; hydrogen bromide; hydroxide; hydrogen; sodium hydride; toluene-4-sulfonic acid; sodium nitrite; palladium on activated charcoal; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1248/cpb.32.2267

Reference yield:

: 87787-00-6
c-3-hydroxy-1-methyl-r-1-cyclohexanecarboxylic acid

: 87787-37-9
methyl 2-bromo-3-<4-(c-3-hydroxy-1-methyl-r-1-cyclohexylmethoxy)phenyl>propionate

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether

2: p-TsOH / diethyl ether / 2 h / Ambient temperature

3: LiAlH₄ / diethyl ether / 1 h / Ambient temperature

4: NaH / dimethylsulfoxide / 3 h / 30 °C

5: 2N HCl / methanol / 1 h / Ambient temperature

6: H₂ / Pd-C / methanol / 760 Torr / Ambient temperature

7: 1.) 47percent HBr, NaNO₂; 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min; 2.) 35 deg C

With copper(I) oxide; hydrogenchloride; lithium aluminium tetrahydride; hydrogen bromide; hydrogen; sodium hydride; toluene-4-sulfonic acid; sodium nitrite; palladium on activated charcoal; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1248/cpb.32.2267