benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

Base Information

• Chemical Name: benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate
• CAS No.: 1057218-08-2
• Molecular Formula: C₂₁H₂₄BrNO₄
• Molecular Weight: 434.33
• Mol file: 1057218-08-2.mol

Synonyms:benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

Chemical Property of benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate

There total 5 articles about benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

(2S)-3-(3-bromophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid (82278-73-7) + benzyl bromide (100-39-0) → benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (1057218-08-2)

Guidance literature:

With potassium carbonate; In acetone; at 25 ℃; for 12h;

Reference yield:

1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-3-bromobenzene (130247-03-9) → benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (1057218-08-2)

Guidance literature:

With hydrogen; (+); In methanol; at 20 ℃; for 72h;

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → benzyl (S)-3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (1057218-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: KOtBu / CH₂Cl₂ / 14 h / -60 - 20 °C

2: H₂ / (+) / methanol / 72 h / 20 °C

With potassium tert-butylate; hydrogen; (+); In methanol; dichloromethane;

upstream raw materials:

1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-3-bromobenzene

m-bromobenzoic aldehyde

Benzyl 2-tert-butoxycarbonylamino-2-(dimethoxyphosphoryl)acetate

(E)-3-(3-Bromo-phenyl)-2-tert-butoxycarbonylamino-acrylic acid benzyl ester