5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

Base Information

Chemical Name:5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine
CAS No.:1205678-11-0
Molecular Formula:C₂₄H₂₇FN₄O₃S
Molecular Weight:470.568
Hs Code.:

Synonyms:5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

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Chemical Property of 5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

Chemical Property:

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Technology Process of 5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

There total 6 articles about 5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1205678-32-5
2-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-6-(piperidin-4-yl)pyridine hydrochloride

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 1205678-11-0
5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

Guidance literature:: With potassium carbonate; In acetonitrile; at 82 ℃; for 4h;

Reference yield:

: 1205678-29-0
methyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)picolinate

: 1205678-11-0
5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: triethylamine / dichloromethane / 1 h / 0 °C

3: caesium carbonate / acetonitrile / 5 h / 70 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

5: potassium carbonate / acetonitrile / 4 h / 82 °C

With hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1205678-30-3
tert-butyl 4-(6-(hydroxymethyl)pyridin-2-yl)piperidine-1-carboxylate

: 1205678-11-0
5-ethyl-2-(4-(6-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)pyridin-2-yl)piperidin-1-yl)pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C

2: caesium carbonate / acetonitrile / 5 h / 70 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

4: potassium carbonate / acetonitrile / 4 h / 82 °C

With hydrogenchloride; potassium carbonate; caesium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;