(S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid

Base Information

• Chemical Name: (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid
• CAS No.: 1428095-47-9
• Molecular Formula: C₃₃H₄₉NO₄
• Molecular Weight: 523.756
• Mol file: 1428095-47-9.mol

Synonyms:(S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid

Chemical Property of (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid

There total 4 articles about (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl N-(3α-hydroxy-5β-cholan-24-oyl)-L-phenylalaninate (1428096-39-2) → (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid (1428095-47-9)

Guidance literature:

methyl N-(3α-hydroxy-5β-cholan-24-oyl)-L-phenylalaninate; With sodium hydroxide; In ethanol; at 20 ℃; for 1h;

With hydrogenchloride; In water;

DOI:10.1021/jm301890k

Reference yield:

Lithocholsaeure-ethoxyameisensaeureanhydrid → (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid (1428095-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2: water; sodium hydroxide / methanol / 20 °C

With water; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201601616

Reference yield:

Lithocholic acid (434-13-9) → (S)-2-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)-3-phenylpropanoic acid (1428095-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane / 0.5 h / 10 - 20 °C

2: triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3: water; sodium hydroxide / methanol / 20 °C

With water; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201601616

upstream raw materials:

Lithocholic acid

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

methyl N-(3α-hydroxy-5β-cholan-24-oyl)-L-phenylalaninate