(R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

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Chemical Name:(R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid
CAS No.:1351523-32-4
Molecular Formula:C₃₀H₃₅N₃O₅S
Molecular Weight:549.691
Hs Code.:

Synonyms:(R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

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Chemical Property of (R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

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Technology Process of (R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

There total 11 articles about (R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1351523-99-3
(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

: 1351523-32-4
(R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 49851-55-0
2,2'-dibromoacetophenone

: 1351523-32-4
(R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 2 h / Reflux

1.2: 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 120 h / Inert atmosphere; Reflux

3.1: HATU / acetonitrile / 0.08 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With potassium carbonate; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 212961-29-0
5-bromo-2-(2-methoxy-ethoxy)-pyridine

: 1351523-32-4
(R)-3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dimethyl sulfoxide / 48 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 120 h / Inert atmosphere; Reflux

3.1: HATU / acetonitrile / 0.08 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With potassium acetate; potassium carbonate; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;