(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

Base Information

Chemical Name:(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate
CAS No.:1351523-99-3
Molecular Formula:C₃₄H₄₃N₃O₅S
Molecular Weight:605.799
Hs Code.:

Synonyms:(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

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Chemical Property of (R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

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Technology Process of (R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

There total 12 articles about (R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1351523-69-7
N-cyclopropyl-4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-amine

: 204637-77-4
(R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester

: 1351523-99-3
(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

Guidance literature:: (R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester; With HATU; In acetonitrile; at 20 ℃; for 0.0833333h;

N-cyclopropyl-4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-amine; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 49851-55-0
2,2'-dibromoacetophenone

: 1351523-99-3
(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / Reflux

1.2: 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 120 h / Inert atmosphere; Reflux

3.1: HATU / acetonitrile / 0.08 h / 20 °C

3.2: 20 °C

With potassium carbonate; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; acetonitrile;

Reference yield:

: 212961-29-0
5-bromo-2-(2-methoxy-ethoxy)-pyridine

: 1351523-99-3
(R)-tert-butyl 3-(cyclopentylmethyl)-4-(cyclopropyl(4-(2-(6-(2-methoxyethoxy)pyridin-3-yl)phenyl)thiazol-2-yl)amino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dimethyl sulfoxide / 48 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 120 h / Inert atmosphere; Reflux

3.1: HATU / acetonitrile / 0.08 h / 20 °C

3.2: 20 °C

With potassium acetate; potassium carbonate; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; dimethyl sulfoxide; toluene; acetonitrile;