3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one

Base Information

• Chemical Name: 3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one
• CAS No.: 886220-25-3
• Molecular Formula: C₁₈H₁₃ClN₂O₃
• Molecular Weight: 340.766

Synonyms:3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one

Chemical Property of 3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one

Chemical Property:

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Technology Process of 3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one

There total 2 articles about 3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C17H10BrClN2O3 (886220-20-8) + acetic anhydride (108-24-7) → 3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one (886220-25-3)

Guidance literature:

for 0.133333h; microwave irradiation;

DOI:10.1002/jhet.5570430214

Reference yield:

4-bromo-3-[p-(acetyl)phenyl]sydnone (84968-90-1) → 3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one (886220-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaOH / ethanol / 0.13 h / microwave irradiation

2: 89 percent / 0.13 h / microwave irradiation

With sodium hydroxide; In ethanol;

DOI:10.1002/jhet.5570430214

Reference yield: 88.0%

3-{4-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one (886220-25-3) + 4-amino-3-mercapto-1,2,4-triazole (4343-75-3) → 3-{4-[8-(4-chloro-phenyl)-7,8-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepin-6-yl]-phenyl}-5-methyl-3H-[1,3,4]oxadiazol-2-one

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 0.166667h; microwave irradiation;

DOI:10.1002/jhet.5570430214

upstream raw materials:

C₁₇H₁₀BrClN₂O₃

acetic anhydride

4-bromo-3-[p-(acetyl)phenyl]sydnone

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