4343-75-3

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL is used as an intermediate in the synthesis of various pharmaceuticals. Its role in drug development is crucial, as it contributes to the formation of active pharmaceutical ingredients, enhancing the therapeutic potential of final products.
Used in Agricultural Chemicals:
In the agricultural sector, 4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL serves as an intermediate for the production of agrochemicals. Its inclusion in these products helps to improve crop protection and yield by targeting pests and diseases effectively.
Used in Dyes and Pigments Industry:
4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL is utilized as a building block in the creation of dyes and pigments. Its chemical structure allows for the development of colorants with specific properties, such as stability and intensity, which are essential for various applications in textiles, plastics, and other industries.
Used as a Chelating Agent in Water Treatment:
4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL functions as a chelating agent in water treatment processes. It binds to metal ions, preventing them from causing scale formation and corrosion, thereby improving the efficiency of water systems and extending the life of equipment.
Used as a Corrosion Inhibitor in Water Treatment:
In addition to its chelating properties, 4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL also acts as a corrosion inhibitor. It protects metal surfaces from degradation, which is particularly important in industrial settings where water systems are prone to corrosion.
Used in Antitumor and Antiviral Research:
4-AMINO-4H-1,2,4-TRIAZOLE-3-THIOL has been studied for its potential antitumor and antiviral properties. Its unique chemical structure may offer new avenues for the development of therapeutic agents to combat cancer and viral infections, although further research is required to fully understand its potential in these areas.

InChI:InChI=1/C2H4N4S/c3-6-1-4-5-2(6)7/h1H,3H2,(H,5,7)

Upstream product

• 1454-96-2 chloromethyl-trichloromethyl sulfide 
• 2231-57-4 Thiocarbohydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 64-18-6 formic acid 
• 592-84-7 n-butyl formate 
• 75-15-0 carbon disulfide 
• 624-84-0 formic acid hydrazide 
• 70028-72-7 C₂H₃N₂OS₂^(1-)*K⁽¹⁺⁾ 

Downstream Products

• 522638-80-8 N-(5-thioxo-1,5-dihydro-[1,2,4]triazol-4-yl)-benzamidine 
• 6421-06-3 3-substituted-4-amino-5-hydrazino-1,2,4-triazole 
• 22184-39-0 6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 3173-10-2 1,2,4-Triazolo<3,4-b>-1,3,4-thiadiazol-2-thiol 
• 3176-50-9 [1,2,4]triazolo[3,4-β][1,3,4]thiadiazol-6-amine 
• 22184-41-4 6-(4-bromophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazine 
• 43029-38-5 6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 22184-40-3 6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 40159-48-6 3-mercapto-4-benzalamino-1,2,4-triazole 

Relevant academic research and scientific papers

Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors

There are currently no treatments for life-threatening infections caused by human polyomaviruses JCV and BKV. We therefore report herein the first crystal structure of the hexameric helicase of JCV large T antigen (apo) and its use to drive the structure-based design of dual JCV and BKV ATP-competitive inhibitors. The crystal structures obtained by soaking our early inhibitors into the JCV helicase allowed us to rapidly improve the biochemical activity of our inhibitors from 18 μM for the early 6-(2-methoxyphenyl)- and the 6-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole hits 1a and 1b to 0.6 μM for triazolopyridine 12i. In addition, we were able to demonstrate measurable antiviral activity in Vero cells for our thiazolopyridine series in the absence of marked cytotoxicity, thus confirming the usefulness of this approach.

C-H Arylation using acyl thiourea ligands: Applications in the synthesis of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

Synthesis of a series of new 3,6-diaryl-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazoles (5a-o) was achieved by phophine free, C-H arylative cross-coupling of 6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (4a-o) with suitably substituted iodoanilines using 1-(2-naphthoyl)-3-(4-bromophenyl)thiourea as a ligand. The requisite triazolothiadiazoles (4a-o) were obtained by the condensation of 4-amino-1,2,4-triazole-3-thiol (3) with suitably substituted aromatic acids in the presence of phosphoryl chloride.

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Synthesis, Antibacterial Activity, and Mechanisms of Novel 6-Sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Derivatives

A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. CoMFA models were established to analyze the quantitative structure-activity relationships on the basis of the EC50 values of the compounds. Th

HCK INHIBITORS FOR THE TREATMENT OF FIBROSIS AND CANCER

Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus: Formula I. The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

4-amino-1,2,4-triazole-3-thione as a promising scaffold for the inhibition of serine and metallo-β-lactamases

The emergence of bacteria that co-express serine-and metallo-carbapenemases is a threat to the efficacy of the available β-lactam antibiotic armamentarium. The 4-amino-1,2,4-triazole-3-thione scaffold has been selected as the starting chemical moiety in the design of a small library of β-Lactamase inhibitors (BLIs) with extended activity profiles. The synthesised compounds have been validated in vitro against class A serine β?Lactamase (SBLs) KPC-2 and class B1 metallo β?Lactamases (MBLs) VIM-1 and IMP-1. Of the synthesised derivatives, four compounds showed cross-class micromolar inhibition potency and therefore underwent in silico analyses to elucidate their binding mode within the catalytic pockets of serine-and metallo-BLs. Moreover, several members of the synthesised library have been evaluated, in combination with meropenem (MEM), against clinical strains that overexpress BLs for their ability to synergise carbapenems.

Synthesis, characterization, and biological activity of some novel Schiff bases and their Co(II) and Ni(II) complexes: A new route for Co3O4 and NiO nanoparticles for photocatalytic degradation of methylene blue dye

Six novel Co(II) and Ni(II)-triazole Schiff base complexes have been successfully synthesized by refluxing the prepared triazole Schiff bases with CoCl2·6H2O or NiCl2·6H2O. The Schiff base ligands were prepared through condensation of 3-R-4-amino-5-hydrazino-1,2,4-triazole with dibenzoylmethane [R[dbnd]H, CH3, and CH2CH3; namely, L1, L2, and L3, respectively]. The prepared Co(II) and Ni(II) complexes have been identified using elemental analysis, FT-IR, UV–Vis, magnetic moment, conductivity, and thermal analysis. On the basis of the conductance results, it was concluded that all the prepared complexes are nonelectrolytes. Interestingly, the prepared Co(II) and Ni(II) complexes were employed as precursors for producing of Co3O4 and NiO nanoparticles, respectively. The produced nanostructures have been identified by XRD, HR-TEM, FT-IR and UV–Vis spectra. The produced nanoparticles revealed good photocatalytic activity for the degradation of methylene blue dye under UV illumination in presence of hydrogen peroxide. The percent of degradation was estimated to be 55.71% in 420.0?min and 90.43% in 360.0?min for Co3O4 and NiO, respectively. Moreover, the synthesized complexes, nano-sized Co3O4, and NiO products have been examined, employing modified Bauer- Kirby method, for antifungal (Candida albicans and Aspergillus flavus) and antibacterial (Staphylococcus aureus and Escherichia coli) activities.

Synthesis and characterization of novel Cu (II) complexes with 3-substituted-4-amino-5-mercapto-1,2,4-triazole Schiff bases: A new route to CuO nanoparticles

Cu (II) complexes, were synthesized with newly derived biologically active 1,2,4-triazole Schiff bases. The Schiff bases were synthesized by condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole with dibenzoylmethane. The synthesized compounds were characterized using elemental analysis, magnetic moment, thermal analysis and spectral tools (FT-IR, 1HNMR, ESR, and UV-Vis spectroscopy). All the synthesized complexes are nonelectrolytes in N,N-dimethylformamide. The synthesized Schiff bases and their Cu (II) complexes have been screened for antibacterial (Escherichia coli & Staphylococcus aureus) and antifungal (Aspergillus flavus & Candida albicans) activity using a modified Bauer-Kirby method. Interestingly, the synthesized Cu (II) complexes were used as precursors for CuO nanoparticles which were characterized using XRD, HR-TEM, FT-IR and UV-Vis spectroscopy. The photocatalytic activity of the prepared CuO nanoparticles was studied by performing the degradation of methylene blue dye under UV illumination in the presence of H2O2 and the results showed that the maximum percent of the degradation of methylene blue dye (MB) was found 96.18% after 360 min.

Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold

APOBEC3G (A3G) is a single-stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. Although A3G can potently restrict Vif-deficient HIV-1 replication by catalyzing excessive levels of G→A hypermutation,

Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity

Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and synthesized. The structures of the synthesized compounds