(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate
CAS No.:1253795-18-4
Molecular Formula:C₁₈H₂₅IN₂O₆
Molecular Weight:492.311
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Suppliers and Price of (S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

There total 4 articles about (S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1253795-10-6
(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(3-iodo-4-methoxyphenyl)acetic acid

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1253795-18-4
(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Guidance literature:: With sodium hydrogencarbonate; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1002/chem.201000924

Reference yield:

: 1086703-03-8
(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

: 1253795-18-4
(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylsilane; trifluoroacetic acid / 24 h / 0 - 20 °C

2: sodium hydrogencarbonate; sodium hydroxide / tetrahydrofuran; water / 8 h / 0 - 20 °C / pH 7

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With triethylsilane; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja207318n

Reference yield:

: C₉H₁₀INO₃

: 1253795-18-4
(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium hydroxide / tetrahydrofuran; water / 8 h / 0 - 20 °C / pH 7

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja207318n