(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

Base Information

• Chemical Name: (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid
• CAS No.: 1086703-03-8
• Molecular Formula: C₁₄H₁₆INO₅
• Molecular Weight: 405.189
• Mol file: 1086703-03-8.mol

Synonyms:(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

Chemical Property of (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

There total 2 articles about (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate (1086703-01-6) → (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid (1086703-03-8)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; at 20 ℃;

DOI:10.1055/s-2008-1078209

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Boc-N-Me-3-Iodo-hydroxyphenylglycine (1338925-48-6) → (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid (1086703-03-8)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; for 2h; Reflux;

DOI:10.1021/ja207318n

Reference yield: 90.0%

(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid (1086703-03-8) → (S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid (1086703-05-0)

Guidance literature:

(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid; With triethylsilane; trifluoroacetic acid; at 20 ℃;

With sodium hydroxide; di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1055/s-2008-1078209

upstream raw materials:

(S)-tert-butyl 4-(4-hydroxyphenyl)-5-oxooxazolidine-3-carboxylate

formaldehyd

Boc-N-Me-3-Iodo-hydroxyphenylglycine

Downstream raw materials:

(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

(S)-methyl 2-((S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetamido)propanoate

C₄₀H₅₁BIN₃O₁₀

C₃₄H₃₉N₃O₈