[5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

Base Information

Chemical Name:[5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone
CAS No.:1215850-03-5
Molecular Formula:C₂₆H₂₂F₃N₃O₂
Molecular Weight:465.475
Hs Code.:

Synonyms:[5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

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Chemical Property of [5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

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Technology Process of [5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

There total 7 articles about [5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1215850-28-4
[5-(5-Hydroxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoromethylphenyl)methanone

: 100-39-0
benzyl bromide

: 1215850-03-5
[5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

Guidance literature:: With caesium carbonate; at 60 ℃; for 4h;

Reference yield:

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 1215850-03-5
[5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

2.1: 3 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

4.1: zinc / methanol / 0.75 h / 20 °C / Inert atmosphere

5.1: sodium nitrite; sulfuric acid; acetic acid / 0 °C

5.2: 5 h / Reflux

5.3: pH 4

6.1: caesium carbonate / 4 h / 60 °C

With sulfuric acid; caesium carbonate; acetic acid; triethylamine; zinc; sodium nitrite; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: (3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate

: 1215850-03-5
[5-(5-benzyloxypyridin-2-yl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl](2-trifluoro-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

2.1: zinc / methanol / 0.75 h / 20 °C / Inert atmosphere

3.1: sodium nitrite; sulfuric acid; acetic acid / 0 °C

3.2: 5 h / Reflux

3.3: pH 4

4.1: caesium carbonate / 4 h / 60 °C

With sulfuric acid; caesium carbonate; acetic acid; zinc; sodium nitrite; In methanol; N,N-dimethyl-formamide;