4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Base Information

Chemical Name:4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide
CAS No.:1313227-64-3
Molecular Formula:C₁₄H₁₆INO₄
Molecular Weight:389.19
Hs Code.:

Synonyms:4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

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Chemical Property of 4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

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Technology Process of 4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

There total 2 articles about 4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4-(benzoyloxy)-6,6-dimethyl-3-methylene-2-trimethylsilyloxy-2,3,5,6-tetrahydro-4H-[1,2]oxazine

: 1313227-64-3
4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Guidance literature:: With iodine; acetic acid; triethylamine; In dichloromethane; at -78 - -30 ℃; for 0.75h; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.078

Reference yield:

: 742062-71-1
benzoic acid 3,6,6-trimethyl-2-oxo-5,6-dihydro-4H-1,2-oxazine-4-yl ester

: 1313227-64-3
4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / -78 °C / Inert atmosphere

2: iodine; acetic acid; triethylamine / dichloromethane / 0.75 h / -78 - -30 °C / Inert atmosphere

With iodine; acetic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2011.04.078

Reference yield: 93.0%

: 1313227-64-3
4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide

: 108-59-8
malonic acid dimethyl ester

: 1313227-82-5
dimethyl 2-[(4-benzoyloxy-6,6-dimethyl-2-oxo-5,6-dihydro-4H-[1,2]oxazin-3-yl)-methyl]malonate

Guidance literature:: malonic acid dimethyl ester; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

4-benzoyloxy-3-(iodomethyl)-6,6-dimethyl-5,6-dihydro-4H-[1,2]oxazine 2-oxide; In N,N-dimethyl-formamide; at -40 - 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.078