N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide
CAS No.:1456693-21-2
Molecular Formula:C₂₅H₃₀INO₅S₂Si
Molecular Weight:643.639
Hs Code.:

Synonyms:N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

There total 7 articles about N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73792-06-0
ethyl-4-amino-2-fluorobenzoate

: 1456693-21-2
N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 20 h / 60 °C

2: acetic acid; Iodine monochloride / 3.67 h / 60 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: diisobutylaluminium hydride / toluene / 3 h / 0 °C

6: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; Iodine monochloride; diisobutylaluminium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1456693-19-8
N-(4-(hydroxymethyl)-2-iodo-5-(methylthio)phenyl)methanesulfonamide

: 1456693-21-2
N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With 1H-imidazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1456693-15-4
ethyl 4-amino-2-(methylthio)benzoate

: 1456693-21-2
N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; Iodine monochloride / 3.67 h / 60 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: diisobutylaluminium hydride / toluene / 3 h / 0 °C

5: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; Iodine monochloride; diisobutylaluminium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;