1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

Base Information

Chemical Name:1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one
CAS No.:1456693-23-4
Molecular Formula:C₃₁H₃₇NO₆S₂Si
Molecular Weight:611.855
Hs Code.:

Synonyms:1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

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Chemical Property of 1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

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Technology Process of 1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

There total 10 articles about 1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1456693-22-3
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

: 1456693-23-4
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 73792-06-0
ethyl-4-amino-2-fluorobenzoate

: 1456693-23-4
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 9 steps

1: N,N-dimethyl-formamide / 20 h / 60 °C

2: acetic acid; Iodine monochloride / 3.67 h / 60 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: diisobutylaluminium hydride / toluene / 3 h / 0 °C

6: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

8: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 8 h / 65 °C / Inert atmosphere

9: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; Iodine monochloride; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1456693-19-8
N-(4-(hydroxymethyl)-2-iodo-5-(methylthio)phenyl)methanesulfonamide

: 1456693-23-4
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 8 h / 65 °C / Inert atmosphere

4: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;