N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Base Information

Chemical Name:N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine
CAS No.:1394848-49-7
Molecular Formula:C₄₈H₄₁N₇O₈
Molecular Weight:843.896
Hs Code.:

Synonyms:N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Suppliers and Price of N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

There total 5 articles about N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1394848-33-9
methyl 3,5-di-O-benzyl-2-deoxy-2-α-phthalimidomethyl-α-D-ribofuranoside

: 138373-37-2
Robin's reagent

: 1394848-49-7
N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Guidance literature:: methyl 3,5-di-O-benzyl-2-deoxy-2-α-phthalimidomethyl-α-D-ribofuranoside; Robin's reagent; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 - 80 ℃; for 1.5h; Inert atmosphere;

With water; sodium hydrogencarbonate; In 1,2-dichloro-ethane; at 20 ℃; diastereoselective reaction;
DOI:10.1039/c2cc34556k

Reference yield:

: 885592-69-8
(2S,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxydihydrofuran-3(2H)-one

: 1394848-49-7
N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere

1.2: 72 h / -78 - 20 °C / Inert atmosphere

2.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 1.5 h / 20 - 80 °C / Inert atmosphere

4.2: 20 °C

With 9-borabicyclo[3.3.1]nonane dimer; trimethylsilyl trifluoromethanesulfonate; sec.-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; cyclohexane; 1,2-dichloro-ethane; 1.2: Wittig reaction / 2.1: Hydroboration reaction / 3.1: Mitsunobu reaction;
DOI:10.1039/c2cc34556k

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 1394848-49-7
N2-acetyl-3',5'-di-O-benzyl-2'-deoxy-O6-(diphenylcarbamoyl)-2'-C-α-phthalimidomethylguanosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 1.5 h / 20 - 80 °C / Inert atmosphere

2.2: 20 °C

With trimethylsilyl trifluoromethanesulfonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane; 1.1: Mitsunobu reaction;
DOI:10.1039/c2cc34556k