[[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester

Base Information

• Chemical Name: [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester
• CAS No.: 256493-23-9
• Molecular Formula: C₂₉H₂₅N₅O₅S
• Molecular Weight: 555.614

Synonyms:[[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester

Chemical Property of [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester

There total 6 articles about [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-cyanophenoxy)acetic acid (1878-82-6) → [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester (256493-23-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CDI / tetrahydrofuran / 50 °C

1.2: tetrahydrofuran / 50 °C

2.1: glacial acetic acid / Heating

3.1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

4.1: pyridine / 20 °C

5.1: K₂CO₃ / acetone / Heating

With pyridine; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1021/jm0109513

Reference yield:

N1-methyl-4-nitrobenzene-1,2-diamine (41939-61-1) → [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester (256493-23-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CDI / tetrahydrofuran / 50 °C

1.2: tetrahydrofuran / 50 °C

2.1: glacial acetic acid / Heating

3.1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

4.1: pyridine / 20 °C

5.1: K₂CO₃ / acetone / Heating

With pyridine; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1021/jm0109513

Reference yield:

4-(1-methyl-5-nitro-1H-benzoimidazol-2-ylmethoxy)-benzonitrile (289913-79-7) → [[2-(4-cyano-phenoxymethyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-acetic acid ethyl ester (256493-23-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

2: pyridine / 20 °C

3: K₂CO₃ / acetone / Heating

With pyridine; hydrogen; potassium carbonate; 10percent Pd/C; In methanol; dichloromethane; acetone;

DOI:10.1021/jm0109513

upstream raw materials:

ethyl bromoacetate

quinoline-8-sulfonyl chloride

(4-cyanophenoxy)acetic acid

N₁-methyl-4-nitrobenzene-1,2-diamine

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