[1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Base Information

Chemical Name:[1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone
CAS No.:1574111-06-0
Molecular Formula:C₂₄H₂₃ClF₂N₂O₂
Molecular Weight:444.909
Hs Code.:

Synonyms:[1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

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Chemical Property of [1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

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Technology Process of [1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

There total 7 articles about [1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1574118-62-9
1-benzyl-4-(4-chlorophenyl)-3-methyl-5-(morpholine-4-carbonyl)-1H-pyrrole-2-carbaldehyde

: 1574111-06-0
[1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In toluene; at 60 ℃;

Reference yield:

: 37629-52-0
(E)-1-(4-chlorophenyl)-2-nitropropene

: 1574111-06-0
[1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,5,7-triazabicyclo[4.4.0]dec-5-ene polystyrene / tetrahydrofuran; isopropyl alcohol / 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; ethanol / 2 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 °C / Cooling with ice

5.1: trichlorophosphate / dichloromethane / 0.25 h / 0 °C

5.2: 1.5 h / 20 °C / Cooling with ice

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 60 °C

With 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;

Reference yield:

: 1574117-15-9
1-benzyl-3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylic acid

: 1574111-06-0
[1-benzyl-3-(4-chlorophenyl)-5-(difluoro-methyl)-4-methyl-1H-pyrrol-2-yl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 °C / Cooling with ice

2.1: trichlorophosphate / dichloromethane / 0.25 h / 0 °C

2.2: 1.5 h / 20 °C / Cooling with ice

3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 60 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; trichlorophosphate; In dichloromethane; toluene;