ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

Base Information

Chemical Name:ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate
CAS No.:222541-29-9
Molecular Formula:C₂₉H₃₀N₂O₄
Molecular Weight:470.568
Hs Code.:

Synonyms:ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

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Chemical Property of ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

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Technology Process of ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

There total 4 articles about ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 222541-11-9
ethyl (E)-<1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-ylidene>acetate

: 222541-29-9
ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.47.329

Reference yield:

: 933-88-0
ortho-toluoyl chloride

: 222541-29-9
ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) sodium hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 18 h

3: 48 percent / H₂ / 10 percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.47.329

Reference yield:

: 137976-09-1
1-(4-aminobenzoyl)-2,3,4,5-tetrahydro1H-1-benzazepin-5-one

: 222541-29-9
ethyl <1-<4-(2-methylbenzoylamino)benzoyl>-2,3,4,5-tetrahydro-1H-1-benzoazepin-5-yl>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) sodium hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 18 h

3: 48 percent / H₂ / 10 percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.47.329