2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide
CAS No.:1403330-47-1
Molecular Formula:C₂₈H₂₄FN₅O₄S
Molecular Weight:545.594
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

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Chemical Property of 2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

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Technology Process of 2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

There total 9 articles about 2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1539264-88-4
6-chloro-N-[2-methoxy-4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-α]pyridin-2-amine

: 1539264-90-8
2-(4-fluorophenyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide

: 1403330-47-1
2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Guidance literature:: 6-chloro-N-[2-methoxy-4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-α]pyridin-2-amine; 2-(4-fluorophenyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; With potassium fluoride; palladium diacetate; catacxium A; In toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;

With potassium phosphate; In toluene; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 450-88-4
1-bromo-4-fluoro-2-methoxybenzene

: 1403330-47-1
2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 65 °C

1.2: 3 h / 0 - 65 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

3.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene / 18 h / Inert atmosphere; Reflux

4.1: palladium diacetate; potassium fluoride; catacxium A / toluene / 0.08 h / 20 °C / Inert atmosphere

4.2: 1 h / 100 °C / Inert atmosphere

With potassium fluoride; potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; palladium diacetate; 3-chloro-benzenecarboperoxoic acid; catacxium A; XPhos; sodium thiomethoxide; In chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1239647-60-9
6-chloro[1,2,4]triazolo[1,5-α]pyridin-2-amine

: 1403330-47-1
2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; potassium phosphate / toluene / 18 h / Inert atmosphere; Reflux

2.1: palladium diacetate; potassium fluoride; catacxium A / toluene / 0.08 h / 20 °C / Inert atmosphere

2.2: 1 h / 100 °C / Inert atmosphere

With potassium fluoride; potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; palladium diacetate; catacxium A; XPhos; In toluene;