(3-chlorophenyl)(imino)(methyl)-λ⁶-sulfanone

Base Information

• Chemical Name: (3-chlorophenyl)(imino)(methyl)-λ⁶-sulfanone
• CAS No.: 22133-00-2
• Molecular Formula: C₇H₈ClNOS
• Molecular Weight: 189.666
• Mol file: 22133-00-2.mol

Synonyms:(3-chlorophenyl)(imino)(methyl)-λ⁶-sulfanone

Chemical Property of (3-chlorophenyl)(imino)(methyl)-λ⁶-sulfanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-chlorophenyl)(imino)(methyl)-λ⁶-sulfanone

There total 2 articles about (3-chlorophenyl)(imino)(methyl)-λ⁶-sulfanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-chloro-3-methylsulfanylbenzene (4867-37-2) → (3-chlorophenyl)(imino)(methyl)-λ6-sulfanone (22133-00-2)

Guidance literature:

With [bis(acetoxy)iodo]benzene; ammonium carbonate; In methanol; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c02615

Reference yield: 81.0%

3-chlorophenyl methyl sulfoxide (13150-73-7) → (3-chlorophenyl)(imino)(methyl)-λ6-sulfanone (22133-00-2)

Guidance literature:

With sodium azide; In neat (no solvent); at 50 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2016.12.031

Reference yield: 88.0%

(3-chlorophenyl)(imino)(methyl)-λ6-sulfanone (22133-00-2) + (4-fluorophenyl)trimethoxysilane (53883-61-7) → N-(4-fluoro)phenyl-S-(3-chloro)phenyl-S-methylsulfoximine

Guidance literature:

With copper(l) iodide; tetrabutyl ammonium fluoride; oxygen; In dichloromethane; at 20 ℃; for 12h; Schlenk technique; Green chemistry;

DOI:10.1021/ol502174n

upstream raw materials:

3-chlorophenyl methyl sulfoxide

1-chloro-3-methylsulfanylbenzene

Refernces

• 1、 Liu, Dong,Liu, Zhao-Ran,Ma, Cong,Jiao, Ke-Jin,Sun, Bing,Wei, Lei,Lefranc, Julien,Herbert, Simon,Mei, Tian-Sheng. "Nickel-Catalyzed N-Arylation of NH-Sulfoximines with Aryl Halides via Paired Electrolysis". supporting information. p. 9444 - 9449. Retrieved 2021/03/29.
• 2、 Wang, Tao,Wang, Yi-Ning,Wang, Rui,Wang, Xi-Sheng. "Rhodium(III)-Catalyzed C?H Alkynylation of N-Methylsulfoximines". supporting information. p. 2449 - 2452. Retrieved 2018/08/17.