methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

Base Information

Chemical Name:methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
CAS No.:1432909-81-3
Molecular Formula:C₁₆H₂₂BClO₄
Molecular Weight:324.612
Hs Code.:

Synonyms:methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

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Chemical Property of methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

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Technology Process of methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

There total 7 articles about methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428761-26-5
methyl 2-(4-bromo-2-chloro-5-methylphenyl)acetate

: 73183-34-3
bis(pinacol)diborane

: 1432909-81-3
methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In tetrahydrofuran; water; toluene; for 18h; Reflux; Inert atmosphere;

Reference yield:

: 57310-39-1
2-bromo-1-chloro-4-methylbenzene

: 1432909-81-3
methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid / water / 3 h / 0 °C / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C

3.1: ruthenium(III) chloride trihydrate; tetra-(n-butyl)ammonium iodide / ethyl acetate / 0 °C

3.2: 2 h / 20 °C

4.1: thionyl chloride / 4.25 h / 100 °C

5.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / water; methanol / 0.67 h / 0 - 20 °C

6.1: copper(ll) bromide; tert.-butylnitrite; toluene-4-sulfonic acid; tetrabutylammomium bromide / acetonitrile / 4 h / 20 °C

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / toluene; tetrahydrofuran; water / 18 h / Reflux; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; tert.-butylnitrite; nickel(II) chloride hexahydrate; ruthenium(III) chloride trihydrate; sulfuric acid; tetrabutylammomium bromide; nitric acid; potassium acetate; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 1-bromo-2-chloro-5-methyl-4-nitrobenzene

: 1432909-81-3
methyl 2-(2-chloro-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C

2.1: ruthenium(III) chloride trihydrate; tetra-(n-butyl)ammonium iodide / ethyl acetate / 0 °C

2.2: 2 h / 20 °C

3.1: thionyl chloride / 4.25 h / 100 °C

4.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / water; methanol / 0.67 h / 0 - 20 °C

5.1: copper(ll) bromide; tert.-butylnitrite; toluene-4-sulfonic acid; tetrabutylammomium bromide / acetonitrile / 4 h / 20 °C

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / toluene; tetrahydrofuran; water / 18 h / Reflux; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; tert.-butylnitrite; nickel(II) chloride hexahydrate; ruthenium(III) chloride trihydrate; tetrabutylammomium bromide; potassium acetate; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; toluene; acetonitrile;