(4S)-6-Chloro-4-((E)-2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Base Information

Chemical Name:(4S)-6-Chloro-4-((E)-2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
CAS No.:214287-99-7
Molecular Formula:C₁₄H₁₂ClF₃N₂O
Molecular Weight:316.71
Hs Code.:
UNII:2498M8N65F
Nikkaji Number:J1.282.390H,J2.033.228J
Wikidata:Q27253830
ChEMBL ID:CHEMBL29274
Mol file:214287-99-7.mol

Synonyms:DPC 083;DPC083

Suppliers and Price of (4S)-6-Chloro-4-((E)-2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DPC083
2.5mg
$ 170.00

Medical Isotopes, Inc.
DPC083
2.5 mg
$ 475.00

Total 1 raw suppliers

Chemical Property of (4S)-6-Chloro-4-((E)-2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Chemical Property:

Vapor Pressure:2.69E-05mmHg at 25°C
Boiling Point:357.7°Cat760mmHg
Flash Point:170.1°C
PSA：41.13000
Density:1.544g/cm³
LogP:4.66570
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:316.0590252
Heavy Atom Count:21
Complexity:464

Purity/Quality:: DPC083 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC1C=CC2(C3=C(C=CC(=C3)Cl)NC(=O)N2)C(F)(F)F
Isomeric SMILES:C1CC1/C=C/[C@]2(C3=C(C=CC(=C3)Cl)NC(=O)N2)C(F)(F)F
Uses DPC 083 is a novel anti-HIV drug used in the treatment of the affliction. Used as a non-nucleoside reverse-transcriptase inhibitor, it helps control the replication of genetic material. It is an analog of efavirenz (E425000).

Technology Process of (4S)-6-Chloro-4-((E)-2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

There total 14 articles about (4S)-6-Chloro-4-((E)-2-cyclopropylvinyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%