(R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile

Base Information

• Chemical Name: (R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile
• CAS No.: 1414889-08-9
• Molecular Formula: C₁₈H₁₃ClF₃N₃O₂
• Molecular Weight: 395.768
• Mol file: 1414889-08-9.mol

Synonyms:(R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile

Chemical Property of (R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile

There total 2 articles about (R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trimethylsilyl cyanide (7677-24-9) + 6-chloro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)hydroquinazolin-2-one (497235-37-7) → (R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile (1414889-08-9)

Guidance literature:

With C₂₉H₂₈F₆N₄OS; In toluene; at 0 ℃; for 24h;

DOI:10.1039/c2cc36307k DOI:10.1039/c2cc36307k

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 6-chloro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)hydroquinazolin-2-one (497235-37-7) → (S)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile (1414889-09-0) + (R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile (1414889-08-9)

Guidance literature:

With C₂₉H₂₈F₆N₄OS; In acetonitrile; at 20 ℃; for 24h; Overall yield = 97 %;

DOI:10.1039/c2cc36307k DOI:10.1039/c2cc36307k

Reference yield: 96.0%

(R)-6-chloro-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile (1414889-08-9) → C18H17ClF3N3O2 (1414889-34-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 24h;

DOI:10.1039/c2cc36307k DOI:10.1039/c2cc36307k

upstream raw materials:

trimethylsilyl cyanide

6-chloro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)hydroquinazolin-2-one

Downstream raw materials:

C₁₈H₁₇ClF₃N₃O₂

C₁₈H₁₄ClF₃N₂O₃

(S,Z)-6-chloro-4-(2-cyclopropylvinyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

(S,E)-6-chloro-4-(2-cyclopropylvinyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one