2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester

Base Information

• Chemical Name: 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester
• CAS No.: 126494-99-3
• Molecular Formula: C₁₉H₂₄O₃S
• Molecular Weight: 332.464

Synonyms:2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester

Chemical Property of 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester

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Technology Process of 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester

There total 6 articles about 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tert-butylmagnesium chloride (677-22-5) + (2R,5S)-trans-4,4-diphenyl-5-methyl-1,3,2-dioxathiolane 2-oxide (126577-49-9) → 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester (126494-99-3) + 2,2-diphenyl-1,2-dihydroxypropyl 2-O-tert-butylsulfinate (126494-96-0,132065-18-0,135790-19-1)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Yields of byproduct given;

DOI:10.1021/jo00021a008

Reference yield: 70.0%

tert-butylmagnesium chloride (677-22-5) + (2R,5S)-trans-4,4-diphenyl-5-methyl-1,3,2-dioxathiolane 2-oxide (126577-49-9) → 2-Methyl-propane-2-sulfinic acid (S)-1-methyl-2,2-diphenyl-ethyl ester + 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester (126494-99-3)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 1h; Yields of byproduct given;

DOI:10.1016/S0040-4039(01)80475-5

Reference yield: 60.0%

3-iodo-2-methyl-2-cyclopentenone (56778-49-5) + tert-butylmagnesium bromide (2259-30-5) → 2-Methyl-propane-2-sulfinic acid (S)-1-methyl-2,2-diphenyl-ethyl ester + 2-Methyl-propane-2-sulfinic acid (S)-2-hydroxy-1,1-diphenyl-propyl ester (126494-99-3)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 1h; Yield given;

DOI:10.1016/S0040-4039(01)80475-5

upstream raw materials:

3-iodo-2-methyl-2-cyclopentenone

tert-butylmagnesium bromide

tert-butylmagnesium chloride

(2R,5S)-trans-4,4-diphenyl-5-methyl-1,3,2-dioxathiolane 2-oxide

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