Magnesium 2-methylpropane chloride

Base Information

• Chemical Name: Magnesium 2-methylpropane chloride
• CAS No.: 677-22-5
• Molecular Formula: C4H9ClMg
• Molecular Weight: 116.873
• Hs Code.: 29319090
• DSSTox Substance ID: DTXSID00987044
• Mol file: 677-22-5.mol

Synonyms:magnesium 2-methylpropane chloride;SCHEMBL474048;DTXSID00987044;AKOS032949747;FT-0654205;A835863;Magnesium chloride 2-methylpropan-2-ide (1/1/1)

Chemical Property of Magnesium 2-methylpropane chloride

Chemical Property:

• Appearance/Colour: clear faint grey to grey, grey-brown or light
• Melting Point: 46oC to 50oC
• Boiling Point: 34 °F
• Flash Point: 34 °F
• PSA: 0.00000
• Density: 0.931 g/mL at 25 °C
• LogP: 2.44360
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Water Solubility.: Miscible with alcohol and water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 116.0243197
• Heavy Atom Count: 6
• Complexity: 4.8

Purity/Quality:

99% purity ^*data from raw suppliers

tert-ButylmagnesiumChloride(2.0MinDiethylEther) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F+;C;F
• Hazard Codes: F+,C,F
• Statements: 12-14/15-19-22-34-66-67-15-11-14-37-17-40
• Safety Statements: 9-16-26-29-33-36/37/39-43-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[C-](C)C.[Mg+2].[Cl-]
• General Description: Tert-Butylmagnesium chloride is a Grignard reagent characterized by the formula (CH3)3CMgCl. It is commonly used in organic synthesis for nucleophilic addition reactions, such as the formation of carbon-carbon bonds with carbonyl compounds (e.g., ketones, aldehydes, or esters). This organomagnesium compound is typically prepared and handled in anhydrous ethereal solvents (e.g., diethyl ether or THF) due to its high reactivity with moisture and air. Its sterically hindered tert-butyl group can influence reaction selectivity, making it useful in controlled synthetic applications. The reagent is often employed in the preparation of tertiary alcohols or other complex organic frameworks.

Technology Process of Magnesium 2-methylpropane chloride

There total 7 articles about Magnesium 2-methylpropane chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ tertiary butyl chloride (507-20-0) + tert-butylmagnesium chloride (677-22-5)

Guidance literature:

Reference yield:

tertiary butyl chloride (507-20-0) + magnesium (7439-95-4) → tert-butylmagnesium chloride (677-22-5)

Guidance literature:

In tetrahydrofuran;

Reference yield:

tertiary butyl chloride (507-20-0) → tert-butylmagnesium chloride (677-22-5)

Guidance literature:

With magnesium anthracene * 3 THF; Product distribution; multistep reaction; other procedures for the preparation of Mg^*; other solvents;

upstream raw materials:

tertiary butyl chloride

9,10-dihydro-9,10-anthracendiyl-tris(THF)magnesium

n-propyltrichlorosilane

magnesium

Downstream raw materials:

3,3-dimethylbutanol

tetramethyl-2,2,3,3 butane

Isobutane

5-hydroxy-2,5,6-trimethyl-heptan-3-one

Refernces

10.1021/jo01375a001

The study focuses on the synthesis and characterization of neopentyl esters of acrylic and methacrylic acids. Neopentyl alcohol, a key reactant, was prepared using two methods: the Whitmore method involving tert-butylmagnesium chloride and pivalyl chloride, and the more practical lithium aluminum hydride reduction of pivalic acid. Neopentyl acrylate was synthesized from neopentyl alcohol and either acryloyl chloride or acrylic acid, while neopentyl methacrylate was prepared from neopentyl alcohol and either methacryloyl chloride or methacrylic acid. The esters' physical properties were measured and reported. The study also highlighted the partly hindered character of neopentyl methacrylate, which affected its saponification process.

Nickel-catalyzed hydrodehalogenation of aryl halides

10.1016/j.jorganchem.2013.01.014

The research focuses on the nickel-catalyzed hydrodehalogenation of aryl and alkyl halides using iso-propyl zinc bromide or tert-butylmagnesium chloride as reagents. The purpose of this study is to develop an efficient and selective method for the transformation of carbon-halogen bonds into carbon-hydrogen bonds, which is crucial for organic synthesis and industry, particularly for the conversion of chlorinated arenes due to their negative environmental and health impacts. The researchers used a straightforward nickel complex as a pre-catalyst, achieving good to excellent yields and chemoselectivities for a variety of aryl and alkyl halides. The study concluded that a well-defined nickel complex, specifically complex 6, could effectively convert a range of aryl and alkyl halides under mild reaction conditions. Future work is planned to deepen the understanding of the reaction mechanism.

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