(S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate
CAS No.:1386981-81-2
Molecular Formula:C₃₀H₃₁ClN₆O₆
Molecular Weight:607.066
Hs Code.:

Synonyms:(S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

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Chemical Property of (S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

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Technology Process of (S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

There total 8 articles about (S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 1386980-68-2
((S)-3-amino-3-phenyl-propyl)-carbamic acid tert-butyl ester

: 1386980-75-1
4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid

: 1386981-81-2
(S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: 4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

((S)-3-amino-3-phenyl-propyl)-carbamic acid tert-butyl ester; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 614-16-4
Benzoylacetonitrile

: 1386981-81-2
(S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4.1: AD column / carbon dioxide; methanol / Resolution of racemate

5.1: hydrazine / methanol / 2 h / Reflux

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 18 h

With lithium aluminium tetrahydride; triethylamine; triphenylphosphine; HATU; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; carbon dioxide; N,N-dimethyl-formamide;

Reference yield:

: 5053-63-4
3-amino-1-phenylpropan-1-ol

: 1386981-81-2
(S)-tert-butyl 3-(4-chloro-3-(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: AD column / carbon dioxide; methanol / Resolution of racemate

4.1: hydrazine / methanol / 2 h / Reflux

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 18 h

With triethylamine; triphenylphosphine; HATU; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; carbon dioxide; N,N-dimethyl-formamide;