N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

Base Information

Chemical Name:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide
CAS No.:1000334-21-3
Molecular Formula:C₂₃H₂₈N₂O₃
Molecular Weight:380.487
Hs Code.:

Synonyms:N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

Chemical Property:

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Technology Process of N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

There total 10 articles about N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1000334-09-7
N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride

: 18496-54-3
phenylbutyric acid chloride

: 1000334-21-3
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

Guidance literature:: With pyridine; at 0 ℃; for 0.25h;

Reference yield:

: 81945-13-3
4-bromo-7-hydroxy-2,3-dihydro-1H-inden-1-one

: 1000334-21-3
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; acetic anhydride / acetic acid / 3 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 40 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 0.5 h

4.1: hydrogen; triethylamine / palladium 10% on activated carbon / ethyl acetate / 1.5 h / 20 °C

5.1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

8.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

9.1: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; nitric acid; acetic anhydride; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1000334-05-3
(6-amino-7-methoxy-2,3-dihydro-1H-inden-1-ylidene)acetonitrile

: 1000334-21-3
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)-4-phenylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia; hydrogen / cobalt / ethanol / 2 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

4: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

5: pyridine / 0.25 h / 0 °C

With pyridine; ammonia; hydrogen; boron tribromide; triethylamine; palladium 10% on activated carbon; cobalt; In tetrahydrofuran; methanol; ethanol; dichloromethane;