(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

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Chemical Name:(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide
CAS No.:1398547-80-2
Molecular Formula:C₂₈H₂₇F₂N₃O₅
Molecular Weight:523.536
Hs Code.:

Synonyms:(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

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Chemical Property of (S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

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Technology Process of (S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

There total 5 articles about (S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 365242-16-6
(S)-5-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

: 1398547-77-7
(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoic acid

: 1398547-80-2
(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

Guidance literature:: (S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)propanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

(S)-5-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one; In dichloromethane; at 20 ℃; for 0.24h;
DOI:10.1021/ja306225u

Reference yield:

: 1398547-93-7
C₈H₆BrF₂NO₃

: 1398547-80-2
(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentoxide / chloroform / 20 °C

2.1: potassium carbonate; N-iodo-succinimide; oxygen / water; 2-methyltetrahydrofuran / 36 h / 0 °C

3.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 4.17 h / 0 - 20 °C

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 0.24 h / 20 °C

With N-iodo-succinimide; phosphorus pentoxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dihydrogen peroxide; oxygen; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; chloroform; water;
DOI:10.1021/ja306225u

Reference yield:

: 1-((1S)-2-bromo-1-(methoxymethoxy)-2-nitroethyl)-3,5-difluorobenzene

: 1398547-80-2
(S)-2-((S)-2-(3,5-difluorophenyl)-2-(methoxymethoxy)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5Hdibenzo[b,d]azepin-7-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; N-iodo-succinimide; oxygen / water; 2-methyltetrahydrofuran / 36 h / 0 °C

2.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 4.17 h / 0 - 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

3.2: 0.24 h / 20 °C

With N-iodo-succinimide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; dihydrogen peroxide; oxygen; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja306225u