Entecavir

Base Information Edit

Chemical Name:Entecavir
CAS No.:142217-69-4
Molecular Formula:C12H15N5O3
Molecular Weight:277.283
Hs Code.:29339900
Mol file:142217-69-4.mol

Synonyms:2-amino-9-[(3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one;ETV;6H-Purin-6-one, 2-amino-1,9-dihydro-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)-;2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidene-cyclopentyl]-3H-purin-6-one;SQ 34676;BMS 200475;Baraclude;6H-Purin-6-one,2-amino-1,9-dihydro-9- [(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2- methylenecyclopentyl]-;Taizhou hikong chemical sell Entecavir;Entecavi;Enteca;Entecavir(monohydrate)--Crude Product;

Suppliers and Price of Entecavir

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Entecavir
10mg
$ 355.00

TRC
Entecavir
250mg
$ 130.00

Tocris
Entecavir ≥98%(HPLC)
10
$ 50.00

Tocris
Entecavir ≥98%(HPLC)
50
$ 198.00

Medical Isotopes, Inc.
Entecavir Monohydrate >98%
10 mg
$ 140.00

Medical Isotopes, Inc.
Entecavir Monohydrate >98%
100 mg
$ 1120.00

Matrix Scientific
Entecavir 95+%
1g
$ 1143.00

Matrix Scientific
Entecavir 95+%
250mg
$ 530.00

DC Chemicals
Entecavir >98%
1 g
$ 900.00

CSNpharm
Entecavir
100mg
$ 340.00

Total 256 raw suppliers

Chemical Property of Entecavir Edit

Chemical Property:

Appearance/Colour:white to off-white/yellow crystalline powder
Melting Point:249-252 °C
Refractive Index:1.837
Boiling Point:734.2 °C at 760 mmHg
PKA:14.22±0.60(Predicted)
Flash Point:397.9 °C
PSA：130.05000
Density:1.81 g/cm³
LogP:-0.24660
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Sparingly)

Purity/Quality:

Above 99% ^*data from raw suppliers

Entecavir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Description Entecavir is a cyclopentyl guanosine analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection, and it is the third nucleoside or nucleotide analog to be marketed for this indication. Lamivudine, a deoxythiacytosine analog, and adefovir dipivoxil, a nucleotide analog, have been marketed since 1998 and 2002, respectively. Entecavir and adefovir are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections.
Uses Entecavir is a new generation of guanine nucleoside analogues oral medicine for treatment of hepatitis B virus infection in, mainly for the treatment of adult patients with viral replication activity and serum transaminase continued to increase, or liver tissue for pathological activity of chronic hepatitis B, is currently down virus the fastest and the most powerful, the mutation rate lowest nucleoside analogues.
Clinical Use Treatment of chronic hepatitis B virus infection in patients >16 years of age.Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day.

Technology Process of Entecavir

There total 357 articles about Entecavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: C₁₃H₁₅N₅O₄

: 142217-69-4,76704-05-7
entecavir

Guidance literature:: With sodium tetrahydroborate; lithium bromide; In methanol; water; at 45 - 50 ℃; for 4h; Reagent/catalyst; Solvent; Temperature;