7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester
• CAS No.: 1080674-54-9
• Molecular Formula: C₂₄H₂₅FN₂O₅S
• Molecular Weight: 472.537
• Mol file: 1080674-54-9.mol

Synonyms:7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Chemical Property of 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

There total 3 articles about 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monomethyl oxalyl chloride (5781-53-3) + 1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one (1080675-72-4) → 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester (1080674-54-9)

Guidance literature:

1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

monomethyl oxalyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

4-fluoro-2-phenylamino-benzoic acid (365-54-8) → 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester (1080674-54-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

2: tetrahydrofuran

3: ethanol / Reflux

4: toluene / 20 °C

5: sodium hexamethyldisilazane / methanol

With sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; toluene; 3: |Michael Addition;

DOI:10.1016/j.bmcl.2012.10.066

Reference yield:

4-fluoro-N-methoxy-N-methyl-2-phenylamino-benzamide (1080675-70-2) → 7-fluoro-3-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester (1080674-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran

2: ethanol / Reflux

3: toluene / 20 °C

4: sodium hexamethyldisilazane / methanol

With sodium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; toluene; 2: |Michael Addition;

DOI:10.1016/j.bmcl.2012.10.066

upstream raw materials:

monomethyl oxalyl chloride

1-(4-fluoro-2-phenylamino-phenyl)-3-(4-methanesulfonyl-piperidin-1-yl)-propan-1-one

4-fluoro-2-phenylamino-benzoic acid

4-fluoro-N-methoxy-N-methyl-2-phenylamino-benzamide