(7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Base Information

Chemical Name:(7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione
CAS No.:1614252-10-6
Molecular Formula:C₂₄H₂₅N₃O₄
Molecular Weight:419.48
Hs Code.:

Synonyms:(7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

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Chemical Property of (7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

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Technology Process of (7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

There total 10 articles about (7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614252-09-3
(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

: 1614252-10-6
(7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 443667-38-7
5-benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

: 1614252-10-6
(7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / 1,4-dioxane / 2 h / Reflux

2: hydrogen; palladium 10% on activated carbon / ethanol / 2.33 h

3: polyphosphoric acid / 1.42 h / 110 °C

4: potassium carbonate / water; acetone / 1.5 h / Reflux

5: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

6: gold(III) chloride / acetonitrile / 0.42 h / 20 °C

7: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

With methanol; gold(III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetone; acetonitrile;

Reference yield:

: 1614252-05-9
(S)-2-(1,3-dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)pentanedioic acid

: 1614252-10-6
(7S)-7-(hydroxymethyl)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: polyphosphoric acid / 1.42 h / 110 °C

2: potassium carbonate / water; acetone / 1.5 h / Reflux

3: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

4: gold(III) chloride / acetonitrile / 0.42 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

With methanol; gold(III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; water; acetone; acetonitrile;