(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

Base Information

Chemical Name:(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate
CAS No.:1614252-09-3
Molecular Formula:C₂₅H₂₅N₃O₅
Molecular Weight:447.491
Hs Code.:

Synonyms:(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

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Chemical Property of (7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

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Technology Process of (7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

There total 9 articles about (7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 534-22-5
2-methylfuran

: 1614252-08-2
(7S)-methyl 10-hydroxy-1,3-dimethyl-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

: 1614252-09-3
(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

Guidance literature:: With gold(III) chloride; In acetonitrile; at 20 ℃; for 0.416667h;

Reference yield:

: 443667-38-7
5-benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

: 1614252-09-3
(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / 1,4-dioxane / 2 h / Reflux

2: hydrogen; palladium 10% on activated carbon / ethanol / 2.33 h

3: polyphosphoric acid / 1.42 h / 110 °C

4: potassium carbonate / water; acetone / 1.5 h / Reflux

5: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

6: gold(III) chloride / acetonitrile / 0.42 h / 20 °C

With methanol; gold(III) chloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In 1,4-dioxane; ethanol; water; acetone; acetonitrile;

Reference yield:

: 1614252-05-9
(S)-2-(1,3-dimethyl-2,4-dioxo-5-phenyl-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)pentanedioic acid

: 1614252-09-3
(7S)-methyl 1,3-dimethyl-10-(5-methylfuran-2-yl)-2,4-dioxo-5-phenyl-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizine-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: polyphosphoric acid / 1.42 h / 110 °C

2: potassium carbonate / water; acetone / 1.5 h / Reflux

3: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

4: gold(III) chloride / acetonitrile / 0.42 h / 20 °C

With methanol; gold(III) chloride; sodium tetrahydroborate; potassium carbonate; In water; acetone; acetonitrile;