Technology Process of N6-benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-8,2'-ethanoadenosine
There total 9 articles about N6-benzoyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-8,2'-ethanoadenosine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal;
In
toluene;
for 55h;
Heating;
DOI:10.1248/cpb.34.15
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) DMSO, (COCl)2; 2.) Et3N / 1.) CH2Cl2, -60 - -70 deg C; 30 min; 2.) CH2Cl2, THF, 30 min; 3.) r.t., 1.5 h
2: 74 percent / CH2Cl2 / 30 h / Ambient temperature
3: NaBH4 / ethanol / 6 h
4: 1.) pyridine, 4 h, 0 deg C; 2.) 0 deg C, overnight
5: 37 percent / LiI / butan-2-one / 0.67 h / Heating
6: 27 percent / AIBN, n-Bu3SnH / benzene / 2.17 h / Heating
7: 83 percent / 5 percent Pd-carbon / toluene / 55 h / Heating
With
sodium tetrahydroborate; palladium on activated charcoal; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; dimethyl sulfoxide; triethylamine; lithium iodide;
In
ethanol; dichloromethane; toluene; butanone; benzene;
DOI:10.1248/cpb.34.15
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 74 percent / CH2Cl2 / 30 h / Ambient temperature
2: NaBH4 / ethanol / 6 h
3: 1.) pyridine, 4 h, 0 deg C; 2.) 0 deg C, overnight
4: 37 percent / LiI / butan-2-one / 0.67 h / Heating
5: 27 percent / AIBN, n-Bu3SnH / benzene / 2.17 h / Heating
6: 83 percent / 5 percent Pd-carbon / toluene / 55 h / Heating
With
sodium tetrahydroborate; palladium on activated charcoal; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium iodide;
In
ethanol; dichloromethane; toluene; butanone; benzene;
DOI:10.1248/cpb.34.15