69304-45-6

Basic information

• Product Name: 3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine
• Synonyms: 3':5'-O-(1,1,3,3-TETRAISOPROPYL-1,3-*DIS ILOXANEDIYL;3:5-O-(1,1,3,3-tetraisopropyl-1,3-*disiloxanedi;(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine;3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine;3',5'-O-(1,1,3,3-Tetraisopropyl- 1,3-Disloxanediyl)Adenosine;3',5'-TIPS-Adenosine;(6AR,8R,9R,9aS)-8-(6-amino-9H-purin-9-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ol
• CAS NO: 69304-45-6
• Molecular Formula: C₂₂H₃₉N₅O₅Si₂
• Molecular Weight: 509.752
• Mol File: 69304-45-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 135-139 °C(lit.)
• Boiling Point: 579.194 °C at 760 mmHg
• Flash Point: 304.086 °C
• Appearance: /
• Density: 1.312g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine(69304-45-6)
• EPA Substance Registry System: 3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine(69304-45-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 69304-45-6(Hazardous Substances Data)

Usage

Uses

3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine (CAS# 69304-45-6) is an adenosine nucleoside used as a building block to prepare DNA and RNA duplexes with exonic splicing enhancer activity.

Upstream product

• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 
• 58-61-7 adenosine 

Downstream Products

• 81705-89-7 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine 2'-(2-chlorophenyl) phosphomonotriazolide 
• 118161-36-7 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁵-<4,4',4''-tris(p-anisoyloxy)trityl>adenosine 
• 5536-17-4 arabinosyl adenine 
• 58-61-7 adenosine 
• 81244-12-4 Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine 
• 114217-96-8 6-amino-9-(3',5'-O-TPDS-2'(S)-deuterio-β-D-threo-pentofuranosyl)purine 
• 81243-98-3 [(4-Methoxy-phenyl)-diphenyl-methyl]-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-amine 
• 81244-14-6 Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 81244-04-4 (2R,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-ol 
• 81244-08-8 Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 81244-01-1 (2R,3R,4R,5R)-2-Hydroxymethyl-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-ol 
• 1276113-10-0 N6-benzoyl-2'-deoxy-α-C-(1-phenylethane-1,2-diol)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine 
• 1276113-12-2 N6-benzoyl-2'-deoxy-2'-C-α-(hydroxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)adenosine 
• 949158-39-8 6-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]adenosine 

Relevant articles and documents

2′-deoxy-2′-α-C-(hydroxymethyl)adenosine as potential anti-HCV agent

Because of the importance of C-branched nucleosides in the discovery of new antiviral molecules, we decided to synthesize 2′-deoxy-2′-α- C-(hydroxymethyl)adenosine as a potential anti-HCV agent. The synthesis of a new adenosine analogue following two different synthetic routes is described. The new C-branched nucleoside was tested for its antiviral activity and found to be inactive.