Technology Process of 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(1,2,3,6-tetrahydropyridin-4-yl)benzamide
There total 9 articles about 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(1,2,3,6-tetrahydropyridin-4-yl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 4-(3-(cyclopentyl(methyl)amino)-5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methylphenyl)-5,6-dihydropyridine-1(2H)-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 2h;
With
sodium hydrogencarbonate;
In
water;
pH=8;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C
2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C
3.1: acetic acid / methanol / 2 h / 20 °C
3.2: 16 h / 20 °C
4.1: caesium carbonate / acetonitrile / 12 h / 80 °C
5.1: sodium hydroxide; water / ethanol / 4 h / 60 °C
5.2: pH 4 - 6
6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 0.25 h / 20 °C
7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1.5 h / 100 °C / Inert atmosphere
8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
8.2: pH 8
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C
2.1: acetic acid / methanol / 2 h / 20 °C
2.2: 16 h / 20 °C
3.1: caesium carbonate / acetonitrile / 12 h / 80 °C
4.1: sodium hydroxide; water / ethanol / 4 h / 60 °C
4.2: pH 4 - 6
5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 0.25 h / 20 °C
6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1.5 h / 100 °C / Inert atmosphere
7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7.2: pH 8
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
