Technology Process of 2-(3-aminophenyl)-2-hydroxyacetamide
There total 3 articles about 2-(3-aminophenyl)-2-hydroxyacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; ammonium formate;
In
methanol;
at 0 - 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: t-butyldimethylsiyl triflate / toluene / 8 h / 100 °C / Inert atmosphere
2: palladium 10% on activated carbon; ammonium formate / methanol / 18 h / 0 - 20 °C
With
palladium 10% on activated carbon; t-butyldimethylsiyl triflate; ammonium formate;
In
methanol; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate; N-methylhydroxyamine hydrochloride; zinc(II) chloride / tetrahydrofuran / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere
1.2: 48 h
2.1: t-butyldimethylsiyl triflate / toluene / 8 h / 100 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; ammonium formate / methanol / 18 h / 0 - 20 °C
With
palladium 10% on activated carbon; t-butyldimethylsiyl triflate; N-methylhydroxyamine hydrochloride; ammonium formate; sodium hydrogencarbonate; zinc(II) chloride;
In
tetrahydrofuran; methanol; toluene;
