935764-13-9Relevant academic research and scientific papers
Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized α-Ketoamides
Nagaki, Aiichiro,Takahashi, Yusuke,Yoshida, Jun-Ichi
supporting information, p. 5327 - 5331 (2016/04/26)
Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α-ketoamides. The present method could be applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent. Go with the flow: Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used to react with electrophiles to give various amides, including α-ketoamides. The method was applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent. PMB=p-methoxybenzyl; FG=functional group.
HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
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Paragraph 0291-0292, (2015/05/26)
The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof.
HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
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Page/Page column 57-58, (2013/09/26)
The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of Formula (I), their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereo
Facile synthesis of primary amides and ketoamides via a palladium-catalysed carbonylation-deprotection reaction sequence
Takács, Eszter,Varga, Csilla,Skoda-F?ldes, Rita,Kollár, László
, p. 2453 - 2456 (2007/10/03)
Various primary amides and ketoamides have been obtained in good yields in a two-step reaction sequence. The first step involves the synthesis of aryl/alkenyl N-tert-butyl amides and aryl N-tert-butyl ketoamides from the corresponding iodides via palladium-catalysed carbonylation in the presence of t-BuNH2 as the nucleophile. Carbonylation was followed by selective cleavage of the t-Bu group using TBDMSOTf as the reagent.
