8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

Base Information

Chemical Name:8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone
CAS No.:299217-37-1
Molecular Formula:C₂₈H₃₀N₂O₄
Molecular Weight:458.557
Hs Code.:

Synonyms:8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

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Chemical Property of 8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

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Technology Process of 8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

There total 7 articles about 8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 299217-23-5
8-[3'-(i-pentyloxy)-5'-(3''-N-BOC-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

: 299217-37-1
8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(00)00179-4

Reference yield:

: 1877-77-6
3-aminobenzenemethanol

: 299217-37-1
8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 4 h / Heating

2: CBr₄; PPh₃ / CH₂Cl₂ / 1 h / 0 °C

3: 41 percent / K₂CO₃ / acetone / 5 h / Heating

4: 92 percent / K₂CO₃; 18-crown-6 / acetone / 5 h / Heating

5: 87 percent / CBr₄; PPh₃ / CH₂Cl₂ / 1 h / 0 °C

6: 85 percent / K₂CO₃ / acetone / 15 h / Heating

7: 87 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With 18-crown-6 ether; carbon tetrabromide; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone; 1: Substitution / 2: Substitution / 3: Alkylation / 4: Alkylation / 5: Substitution / 6: Alkylation / 7: carbamate cleavage;
DOI:10.1016/S0040-4020(00)00179-4

Reference yield:

: 118684-32-5
[3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide

: 299217-37-1
8-[3'-(3-i-pentyloxy)-5'-(3''-aminobenzyloxy)benzyloxy]-2-[1H]-quinolinone

Guidance literature:: Multi-step reaction with 5 steps

1: 41 percent / K₂CO₃ / acetone / 5 h / Heating

2: 92 percent / K₂CO₃; 18-crown-6 / acetone / 5 h / Heating

3: 87 percent / CBr₄; PPh₃ / CH₂Cl₂ / 1 h / 0 °C

4: 85 percent / K₂CO₃ / acetone / 15 h / Heating

5: 87 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With 18-crown-6 ether; carbon tetrabromide; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In dichloromethane; acetone; 1: Alkylation / 2: Alkylation / 3: Substitution / 4: Alkylation / 5: carbamate cleavage;
DOI:10.1016/S0040-4020(00)00179-4