[4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

Base Information

Chemical Name:[4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester
CAS No.:344951-20-8
Molecular Formula:C₂₁H₃₅N₄O₈PS
Molecular Weight:534.571
Hs Code.:

Synonyms:[4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

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Chemical Property of [4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

Chemical Property:

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Technology Process of [4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

There total 9 articles about [4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 344951-18-4
[7-(2-bromo-acetylamino)-heptyl]-[2-(2-nitro-benzenesulfonylamino)-ethyl]-phosphoramidic acid diethyl ester

: 344951-20-8
[4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃;
DOI:10.1016/S0040-4039(02)01756-2

Reference yield:

: 18226-11-4
N-(2-hydroxy-ethyl)-2-nitro-benzenesulfonamide

: 344951-20-8
[4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

2: 90 percent / KOH / benzene; H₂O / 1 h / 20 °C

3: 59 percent / tetrahydrofuran / 0.33 h / 20 °C

4: 63 percent / Et₃N / tetrahydrofuran / -78 °C

5: 67 percent / Et₃N / CH₂Cl₂

6: 85 percent / TFA / CH₂Cl₂

7: 89 percent / Na₂CO₃ / tetrahydrofuran / -15 °C

8: 90 percent / K₂CO₃ / acetonitrile / 60 °C

With potassium hydroxide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4039(02)01756-2

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 344951-20-8
[4-(2-Nitro-benzenesulfonyl)-6-oxo-1,4,7-triaza-cyclotetradec-1-yl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

2: 60 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

3: 90 percent / KOH / benzene; H₂O / 1 h / 20 °C

4: 59 percent / tetrahydrofuran / 0.33 h / 20 °C

5: 63 percent / Et₃N / tetrahydrofuran / -78 °C

6: 67 percent / Et₃N / CH₂Cl₂

7: 85 percent / TFA / CH₂Cl₂

8: 89 percent / Na₂CO₃ / tetrahydrofuran / -15 °C

9: 90 percent / K₂CO₃ / acetonitrile / 60 °C

With potassium hydroxide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4039(02)01756-2