4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

Base Information

Chemical Name:4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide
CAS No.:1616461-82-5
Molecular Formula:C₂₈H₂₉ClN₂O₂S
Molecular Weight:493.069
Hs Code.:

Synonyms:4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

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Chemical Property of 4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

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Technology Process of 4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

There total 5 articles about 4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4651-82-5
2-amino-3-cyanothiophene

: 4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]benzoyl chloride

: 1616461-82-5
4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

Guidance literature:: With dmap; triethylamine; In toluene; Reflux; Inert atmosphere;
DOI:10.1039/c4nj00298a

Reference yield:

: 2420-16-8
4-hydroxy-3-chlorobenzaldehyde

: 1616461-82-5
4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere

2.1: potassium carbonate; 18-crown-6 ether / dichloromethane; tetrahydrofuran / 1 h / Inert atmosphere

2.2: Reflux; Inert atmosphere

3.1: potassium hydroxide / ethanol; water / 8 h / Inert atmosphere

3.2: 8 h / Inert atmosphere

4.1: triethylamine; dmap / toluene / Reflux; Inert atmosphere

With dmap; 18-crown-6 ether; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.2: |Wittig Olefination;
DOI:10.1039/c4nj00298a

Reference yield:

: 108898-23-3
3-chloro-4-(octyloxy)benzaldehyde

: 1616461-82-5
4-[(E)-2-[3-chloro-4-(octyloxy)phenyl]ethenyl]-N-(3-cyanothiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; 18-crown-6 ether / dichloromethane; tetrahydrofuran / 1 h / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: potassium hydroxide / ethanol; water / 8 h / Inert atmosphere

2.2: 8 h / Inert atmosphere

3.1: triethylamine; dmap / toluene / Reflux; Inert atmosphere

With dmap; 18-crown-6 ether; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1.2: |Wittig Olefination;
DOI:10.1039/c4nj00298a