(R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:(R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid
CAS No.:1465060-71-2
Molecular Formula:C₂₇H₃₂N₂O₃
Molecular Weight:432.563
Hs Code.:

Synonyms:(R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Suppliers and Price of (R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

There total 3 articles about (R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-methyl 1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylate trifluoroacetic acid salt

: 1465060-71-2
(R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Guidance literature:: With methanol; sodium hydroxide; at 60 ℃; for 4h;

Reference yield:

: 1465060-57-4
(R)-methyl 1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylate 2,2,2-trifluoroacetate

: 1465060-71-2
(R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Guidance literature:: With methanol; sodium hydroxide; at 60 ℃; for 4h;

Reference yield:

: (R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride

: 113020-21-6
1,1-cyclopropanedicarboxylic acid monomethyl ester

: 1465060-71-2
(R)-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: HATU; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2: methanol; sodium hydroxide / 4 h / 60 °C

With methanol; triethylamine; HATU; sodium hydroxide; In N,N-dimethyl-formamide;