113020-21-6Relevant articles and documents
Spontaneous reaction of malonyl peroxides with methanol
Lapitskaya, Margarita A.,Vil, Vera A.,Vasil'eva, Ludmila L.,Daeva, Elena D.,Terent'ev, Alexander O.,Pivnitsky, Kasimir K.
, p. 243 - 245 (2017)
The spontaneous reaction of disubstituted malonyl peroxides (MPOs) with methanol affording monopermalonic acid monomethyl esters is fast (minutes) for lower homologues but is sharply decelerated (days) for the higher ones. Spirocyclopropyl-MPO is an excep
Alcoholysis of malonyl peroxides to give peracids
Lapitskaya, Margarita A.,Vil', Vera A.,Daeva, Elena D.,Terent'Ev, Alexander O.,Pivnitsky, Kasimir K.
, p. 14 - 15 (2016)
Potassium acetate catalyzed alcoholysis of spirocycloalkyl malonyl peroxides affords 1-alkoxycarbonylcycloalkane-1-percarboxylic acids which are suitable for epoxidation of olefins.
PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0066, (2018/09/21)
The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a preparation process thereof and a composition comprising the compound, and a use thereof as a multi-target protein kinase inhibitor in the preparation of a medicament for the treatment of diseases that are associated with protein kinase, especially c-Met, such as cancer and the like. The compound represented by formula I has potent inhibitory activity on tumor cells with overexpression of c-Met kinase, can effectively target c-Met-mediated signaling pathway, and can be used in the treatment of diseases such as cancer and the like that is caused by the overexpression of c-Met kinase.