1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone

Base Information

• Chemical Name: 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone
• CAS No.: 155623-52-2
• Molecular Formula: C₁₇H₂₈O₃SSi
• Molecular Weight: 340.559
• Mol file: 155623-52-2.mol

Synonyms:1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone

Chemical Property of 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone

There total 4 articles about 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

phenyl methoxymethyl sulfone (15251-78-2) + 4-trimethylsilyl-1-iodo-4-pentene (139929-54-7) → 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone (155623-52-2)

Guidance literature:

With tert.-butyl lithium; In 1,2-dimethoxyethane; pentane; at -78 ℃; for 1.5h;

DOI:10.1016/S0040-4020(01)80798-5

Reference yield:

methoxymethyl phenyl sulfide (13865-50-4) → 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone (155623-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / oxone / methanol; H₂O / 25 °C / pH 4

2: 83 percent / t-BuLi / 1,2-dimethoxy-ethane; pentane / 1.5 h / -78 °C

With Oxone; tert.-butyl lithium; In methanol; 1,2-dimethoxyethane; water; pentane;

DOI:10.1016/S0040-4020(01)80798-5

Reference yield:

4-((trimethylsilyl)methyl)pent-4-en-1-ol (99667-09-1) → 1-methoxy-5-trimethylsilylmethyl-5-hexen-1-yl-phenyl sulfone (155623-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 3.8 g / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

2: 83 percent / NaI, NaHCO₃ / acetone / 25 °C

3: 83 percent / t-BuLi / 1,2-dimethoxy-ethane; pentane / 1.5 h / -78 °C

With tert.-butyl lithium; sodium hydrogencarbonate; triethylamine; sodium iodide; In 1,2-dimethoxyethane; dichloromethane; acetone; pentane;

DOI:10.1016/S0040-4020(01)80798-5

upstream raw materials:

phenyl methoxymethyl sulfone

4-trimethylsilyl-1-iodo-4-pentene

methoxymethyl phenyl sulfide

4-((trimethylsilyl)methyl)pent-4-en-1-ol

Downstream raw materials:

3-methylenecyclohexyl methyl ether