Methoxymethyl Phenyl Sulfone

Base Information

• Chemical Name: Methoxymethyl Phenyl Sulfone
• CAS No.: 15251-78-2
• Molecular Formula: C8H10O3S
• Molecular Weight: 186.232
• Mol file: 15251-78-2.mol

Synonyms:methoxymethyl phenyl sulfone;phenyl methoxymethyl sulfone;Methoxymethanesulfonyl-benzene;

Chemical Property of Methoxymethyl Phenyl Sulfone

Chemical Property:

• Melting Point: 71.0 to 75.0 °C
• PSA: 51.75000
• LogP: 2.14500

Purity/Quality:

97% ^*data from raw suppliers

Methoxymethylsulfonylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methoxymethyl Phenyl Sulfone

There total 8 articles about Methoxymethyl Phenyl Sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methoxymethyl phenyl sulfide (13865-50-4) → phenyl methoxymethyl sulfone (15251-78-2)

Guidance literature:

With potassium permanganate; In dichloromethane; water; for 48h; Ambient temperature;

DOI:10.1021/jo01306a019

Reference yield:

methoxymethyl phenyl sulfide (13865-50-4) → phenyl methoxymethyl sulfone (15251-78-2) + (S)-phenyl methoxymethyl sulfoxide (128854-34-2) + (R)-methoxymethyl phenyl sulfoxide (140696-20-4)

Guidance literature:

With dihydrogen peroxide; 6,6′-bis[(S)-4-isopropyloxazolin-2-y1]-2,2′-bipyridine; iron(II) chloride; In tetrahydrofuran; water; at -25 ℃; for 3h; enantioselective reaction;

DOI:10.1002/ejoc.201601597

Reference yield:

thiophenol (108-98-5) → phenyl methoxymethyl sulfone (15251-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) KO-t-C₄H₉ / 1) dry THF, 0 deg C 2) MeOH a) 30 min 0 deg C b) 15 min room temperature

2: 95 percent / KMnO₄ / CH₂Cl₂; H₂O / 48 h / Ambient temperature

With potassium permanganate; potassium tert-butylate; In dichloromethane; water;

DOI:10.1021/jo01306a019

upstream raw materials:

Dimethoxymethane

Benzenesulfinic acid

methoxymethyl phenyl sulfide

bromethyl methyl ether

Downstream raw materials:

4-(Benzenesulfonyl-methoxy-methyl)-2,6-dimethyl-heptan-4-ol

(1α,5α)-6-bicyclo<3.2.0>heptan-6-ol

(1α,6α)-7-bicyclo<4.2.0>octan-7-ol

(1α,6α)-7--2-oxabicyclo<4.2.0>octan-7-ol