(R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955407-65-5
Molecular Formula:C₂₆H₂₈FN₃O
Molecular Weight:417.526
Hs Code.:

Synonyms:(R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Technology Process of (R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 9 articles about (R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955406-35-6
trifluoro-methanesulfonic acid 3,5-dimethyl-4-[(R)-2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 1765-93-1
4-fluoroboronic acid

: 955407-65-5
(R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: trifluoro-methanesulfonic acid 3,5-dimethyl-4-[(R)-2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester; 4-fluoroboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 80 ℃; for 2h;

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 955406-33-4
(R)-3-(4-Benzyloxy-2,6-dimethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

: 955407-65-5
(R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium hydroxide on carbon / ethanol / 48 h / 1810.07 Torr

2.1: pyridine / 2 h / 0 - 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 80 °C

3.2: 20 °C

With pyridine; hydrogen; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; ethanol; water;

Reference yield:

: 955406-32-3
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dimethyl-benzyl)-4-oxo-butyraldehyde

: 955407-65-5
(R)-3-(4'-Fluoro-3,5-dimethyl-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; acetonitrile / 1 h / 20 °C

1.2: 20 °C

2.1: hydrogen / palladium hydroxide on carbon / ethanol / 48 h / 1810.07 Torr

3.1: pyridine / 2 h / 0 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 2 h / 80 °C

4.2: 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; acetonitrile;